Human Disease and Mouse Model Detail

Human Disease

Term: Thyroid Carcinoma, Familial Medullary; MTC
OMIM ID: 155240

Synonyms

Fmtc; MTC1

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Prlr

PRLR

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Ntrk1	NTRK1
Ret	RET

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype				Ref(s)
Allelic Composition		Note	Genetic Background	Ref(s)
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Prlr^tm1Cnp/Prlr^tm1Cnp			involves: 129/Sv * 129P2/OlaHsd	J:101609
No similarity to the expected human disease phenotype was found.²
NOT	Ret^tm2.1Cos/Ret^tm2.1Cos		involves: 129S1/Sv * C57BL/6J * FVB/N	J:60659
NOT	Ret^tm2.1Cos/Ret⁺		involves: 129S1/Sv * C57BL/6J * FVB/N	J:60659

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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