About   Help   FAQ
Human Disease and Mouse Model Detail
Human Disease

Term: Leukemia, Chronic Lymphocytic; CLL
OMIM ID: 151400

Synonyms Leukemia, Chronic Lymphatic
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Cd19 CD19
Igha none identified
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Transgenes and
other mutation types
Del(14Trim13-Dleu2)4Rdf   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Del(14Trim13-Rnaseh2b)6Rdf
Is(14)1Rdf
Is(14)2Rdf
Is(14)5Rdf
Mirc30
Tg(BCL2/IGH)#Jcre
Tg(H2-K/Igh-Traf2*)#Ywc
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Tg(Igh-TCL1A)1Ypek
Tg(Igh-V186.2-TCL1A)3Cro
Tg(Lck-TNFSF13)3919Mhah
Tg(Tnfsf13b)1Fma

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.1
Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0		   involves: 129S1/Sv * C57BL/6 * DBA/2J J:166158
Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946
Is(14)1Rdf/Is(14)1Rdf
Is(14)5Rdf/Is(14)5Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Models involving transgenes or other mutation types.2
Del(14Trim13-Dleu2)4Rdf/Del(14Trim13-Dleu2)4Rdf   involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946
Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Ighatm1(Myc)Janz/Igha+
Tg(Tnfsf13b)1Fma/0		   involves: 129S1/Sv * C57BL/6 * DBA/2J J:166158
Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946
Is(14)1Rdf/Is(14)1Rdf
Is(14)5Rdf/Is(14)5Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf
Cd19tm1(cre)Cgn/Cd19+		 3 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:179879
Mirc30tm1.2Rdf/Mirc30tm1.2Rdf   involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 J:156946
Tg(BCL2/IGH)#Jcre/0
Tg(H2-K/Igh-Traf2*)#Ywc/0		   involves: BALB/c * C57BL/6 * CBA/J * FVB/N * SJL/J * SWR/J J:94116
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0   FVB/N-Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro J:162077
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
Tg(Igh-V186.2-TCL1A)3Cro/0		   involves: C3H * C57BL/6 * FVB/N J:162077
Tg(Igh-TCL1A)1Ypek/0   FVB/N-Tg(Igh-TCL1A)1Ypek J:160184
Tg(Igh-V186.2-TCL1A)3Cro/0   involves: C3H * C57BL/6 J:76574
Tg(Lck-TNFSF13)3919Mhah/0   B6.Cg-Tg(Lck-TNFSF13)3919Mhah J:94628

1The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
2Models involving transgenes or other mutation types may also appear in other sections of the table.
3Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory