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Human Disease and Mouse Model Detail
Human Disease

Term: Hypertension, Essential
OMIM ID: 145500

Synonyms EHT
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Nos3 NOS3
  mousehuman...both mouse and human orthologous genes.
     
Eln ELN
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Add1 ADD1
Agt AGT
Agtr1b AGTR1
Atp1b1 ATP1B1
Cyp3a41a CYP3A5
Ece1 ECE1
Gnb3 GNB3
Nos2 NOS2
Pnmt PNMT
Ptgis PTGIS
Rgs5 RGS5
Sele SELE
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Nos3tm1Gdk/Nos3tm1Gdk   involves: 129P2/OlaHsd * C57BL/6 J:46061
Nos3tm1Plh/Nos3tm1Plh   involves: 129S4/SvJae J:28778
Nos3tm1Unc/Nos3tm1Unc   involves: 129P2/OlaHsd J:103153
Models with phenotypic similarity to human disease where etiologies are distinct.2
Elntm1Dyl/Eln+   B6.129-Elntm1Dyl J:86535
No similarity to the expected human disease phenotype was found.3
NOT Tnfrsf1btm1Imx/Tnfrsf1btm1Imx   involves: 129S7/SvEvBrd * C57BL/6 J:45147

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory