Human Disease and Mouse Model Detail

Human Disease

Term: Hyperparathyroidism 1; HRPT1
OMIM ID: 145000

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Casr	CASR
Men1	MEN1

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

CDC73

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Casr^BCH002/Casr^BCH002		C3HeB/FeJ-Casr^BCH002	J:183993
Casr^BCH003/Casr^BCH003		C3HeB/FeJ-Casr^BCH003	J:183993
Casr^BCH004/Casr^BCH004		C3HeB/FeJ-Casr^BCH004	J:183993
Casr^BCH007/Casr^BCH007		C3HeB/FeJ-Casr^BCH007	J:183993
Casr^BCH011/Casr^BCH011		C3HeB/FeJ-Casr^BCH011	J:183993
Casr^BCH013/Casr^BCH013		C3HeB/FeJ-Casr^BCH013	J:183993
Men1^tm1Zqw/Men1⁺		involves: 129/Sv * 129P2/OlaHsd	J:85302

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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