Human Disease and Mouse Model Detail

Human Disease

Term: Attention Deficit-Hyperactivity Disorder; ADHD
OMIM ID: 143465

Synonyms

Hyperactivity of Childhood

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Slc6a3

SLC6A3

...both mouse and human orthologous genes.

Cm	none identified

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Drd4	DRD4
Drd5	DRD5

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

Tg(Camk2a-tTA)1Mmay		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(tetO-Csnk1d)#Mfla

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Slc6a3^tm1Hhg/Slc6a3^tm1Hhg		B6.129X1-Slc6a3^tm1Hhg	J:183177
Slc6a3^tm2Mca/Slc6a3^tm2Mca		involves: 129S1/Sv * 129X1/SvJ	J:67549
Models with phenotypic similarity to human disease where etiologies are distinct.²
Cm/+		C3Sn.Cg-Cm/J	J:1371
Models involving transgenes or other mutation types.³
Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-Csnk1d)#Mfla/0		involves: 129/Sv * C57BL/6	J:158611

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
³Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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