Human Disease and Mouse Model Detail

Human Disease

Term: Hemoglobin--Beta Locus; HBB
OMIM ID: 141900

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Hba-a1	HBA2
Hbb-b1	none identified

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Transgenes and
other mutation types

Hbb

Characteristics of this human disease are associated with transgenes and other mutation types in mouse.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Hba-a1^tm1Shs/Hba-a1⁺		involves: C57BL/6CrSlc	J:81902
Hbb-b1^tm1Shs/Hbb-b1⁺		involves: C57BL/6CrSlc	J:81902
Hbb-b1^tm1Shs/Hbb-b1^tm1Shs		involves: C57BL/6	J:78271
Models involving transgenes or other mutation types.²
Hbb^d4/Hbb^d4		involves: 101/H	J:7972

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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