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Human Disease and Mouse Model Detail
Human Disease

Term: Gilles De La Tourette Syndrome; GTS
OMIM ID: 137580

Synonyms Tourette Syndrome; TS
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Slitrk1 SLITRK1
  mousehuman...both mouse and human orthologous genes.
     
Met MET
Slc6a3 SLC6A3
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Transgenes and
other mutation types
Tg(DRD1-ctxA)7Burt   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Slitrk1tm1Jaru/Slitrk1tm1Jaru   B6.129P2-Slitrk1tm1Jaru J:145441
Models with phenotypic similarity to human disease where etiologies are distinct.2
Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0		 4 involves: 129P2/OlaHsd * C57BL/6J * FVB J:170554
Slc6a3tm2Mca/Slc6a3tm2Mca   involves: 129S1/Sv * 129X1/SvJ J:176799
Models involving transgenes or other mutation types.3
Tg(DRD1-ctxA)7Burt/0   C.Cg-Tg(DRD1-ctxA)7Burt J:133268, J:133402

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory