Human Disease and Mouse Model Detail

Human Disease

Term: Exudative Vitreoretinopathy 1; EVR1
OMIM ID: 133780

Synonyms

Exudative Vitreoretinopathy, Familial, Autosomal Dominant; Fevr, Autosomal Dominant

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Fzd4

FZD4

...both mouse and human orthologous genes.

Lrp5

LRP5

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Fzd4^tm1Nat/Fzd4^tm1Nat		involves: 129S1/Sv * 129X1/SvJ	J:158585

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2013 MGI 5.12