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Human Disease and Mouse Model Detail
Human Disease

Term: Multiple Endocrine Neoplasia, Type I; MEN1
OMIM ID: 131100

Synonyms Endocrine Adenomatosis, Multiple; MEA I; MEN I
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Men1 MEN1
  mousehuman...both mouse and human orthologous genes.
     

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Men1tm1.1Gfk/Men1+   involves: 129T2/SvEms * C57BL/6 J:116086
Men1tm1.2Zqw/Men1tm1.2Zqw
Tg(Ins2-cre)23Herr/0		 2 involves: 129P2/OlaHsd * C57BL/6J * CBA/J J:85133
Men1tm1Ctre/Men1tm1Ctre
Tg(Pdx1-cre)89.1Dam/0		 2 involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N J:146440
Men1tm1Rvt/Men1+   involves: 129 * C57BL/6 J:191261
Men1tm1Zqw/Men1+   involves: 129/Sv * 129P2/OlaHsd J:85302
Men1tm2.1Gfk/Men1+   involves: 129T2/SvEms * C57BL/6 J:116086

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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04/03/2013
MGI 5.12 		The Jackson Laboratory