About   Help   FAQ
Human Disease and Mouse Model Detail
Human Disease

Term: Multiple Sclerosis, Susceptibility To; MS
OMIM ID: 126200

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Mog MOG
Prf1 PRF1
Rag2 RAG2
Tnfrsf1a TNFRSF1A
Tnfrsf1b TNFRSF1B
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
H2-Ab1 HLA-DQB1
H2-Eb1 HLA-DRB1
Pdcd1 PDCD1
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Igh-J   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Cd4-CD4)2362Litt
Tg(Gfap-TNF*)K21Gkl
Tg(HLA-DR2)#Lfug
Tg(Mbp-Pad2)28Fgm
Tg(PLP1*)4Rsj
Tg(Tcra2D2,Tcrb2D2)1Kuch
Tg(TCROb.1A12)#Lfug
Tg(Tnf)6074Gkl

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 J:151335
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch J:151335
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S2/SvPas * C57BL/6 J:151335
Mogtm1Dpd/Mogtm1Dpd
Rag2tm1Cgn/Rag2tm1Cgn
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S2/SvPas * C57BL/6 J:151335
Prf1tm1Sdz/Prf1tm1Sdz   C57BL/6-Prf1tm1Sdz/J J:120427
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
  involves: C57BL/6 * DBA/2 J:134764
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
  involves: 129P2/OlaHsd * C57BL/6 * CBA J:106592
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
  involves: 129S2/SvPas * C57BL/6 * CBA J:106592
Models involving transgenes or other mutation types.2
Igh-Jtm1Aigl/Igh-J+
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:151335
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 J:151335
Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch J:151335
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S2/SvPas * C57BL/6 J:151335
Mogtm1Dpd/Mogtm1Dpd
Rag2tm1Cgn/Rag2tm1Cgn
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
  involves: 129S2/SvPas * C57BL/6 J:151335
Rag2tm1.1Cgn/Rag2tm1.1Cgn
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
  involves: C57BL/6 * DBA/2 J:134764
Tg(Cd4-CD4)2362Litt/0
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
  involves: C57BL/6 * DBA/2 * SJL J:134764
Tg(Gfap-TNF*)K21Gkl/0   involves: C57BL/6 * CBA J:106592
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
  involves: 129P2/OlaHsd * C57BL/6 * CBA J:106592
Tg(HLA-DR2)#Lfug/0
Tg(TCROb.1A12)#Lfug/0
  involves: C57BL/6 * DBA/2 J:134764
Tg(Mbp-Pad2)28Fgm/Tg(Mbp-Pad2)28Fgm   involves: CD-1 J:142650
Tg(Mbp-Pad2)28Fgm/0   involves: CD-1 J:142650
Tg(PLP1*)4Rsj/0   involves: CD-1 J:161344
Tg(Tnf)6074Gkl/0   involves: C57BL/6 * CBA J:106592
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
  involves: 129S2/SvPas * C57BL/6 * CBA J:106592

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/03/2013
MGI 5.12
The Jackson Laboratory