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Human Disease and Mouse Model Detail
Human Disease

Term: Diabetes Mellitus, Noninsulin-Dependent; NIDDM
OMIM ID: 125853

Synonyms Diabetes Mellitus, Type II; T2D; Noninsulin-Dependent Diabetes Mellitus
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Akt2 AKT2
Gck GCK
Hmga1 HMGA1
Hnf1a HNF1A
Irs1 IRS1
Irs2 IRS2
Pdx1 PDX1
Slc2a4 SLC2A4
  mousehuman...both mouse and human orthologous genes.
     
a ASIP
Ctf1 CTF1
Cyb5r4 CYB5R4
Fem1b FEM1B
Htr2c HTR2C
Lepr LEPR
Mafa MAFA
Pbx1 PBX1
Phox2a PHOX2A
Ppp1r3a PPP1R3A
Ppp1r3c PPP1R3C
Slc2a2 SLC2A2
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Abcc8 ABCC8
Cdkal1 CDKAL1
Enpp1 ENPP1
Gcgr GCGR
Gpd2 GPD2
Hnf1b HNF1B
Hnf4a HNF4A
Igf2bp2 IGF2BP2
Il6 IL6
Kcnj11 KCNJ11
Lipc LIPC
Mapk8ip1 MAPK8IP1
Mtnr1b MTNR1B
Neurod1 NEUROD1
Pax4 PAX4
Pparg PPARG
Ptpn1 PTPN1
Retn RETN
Slc30a8 SLC30A8
Tcf7l2 TCF7L2
Wfs1 WFS1
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(aP2-SREBF1c)9884Reh   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(APOB)11Rub
Tg(APPswe,PSEN1dE9)85Dbo
Tg(Ckm-IGF1R*K1003R)1Dlr
Tg(UcpDta)1Kz
Timo

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Akt2tm1.1Mbb/Akt2tm1.1Mbb   involves: 129P2/OlaHsd * C57BL/6 J:71491
Gcktm1Tka/Gcktm1Tka   involves: 129X1/SvJ * ICR J:30334
Gcktm1Tka/Gck+
Irs1tm1Tka/Irs1tm1Tka		   involves: 129X1/SvJ * C57BL/6 * CBA * ICR J:38899
Hmga1tm1Brun/Hmga1+   Not Specified J:99652
Hmga1tm1Brun/Hmga1tm1Brun   Not Specified J:99652
Hnf1atm1.1Ylee/Hnf1atm1.1Ylee   involves: 129X1/SvJ * C57BL/6J J:47008
Irs1tm1Jos/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0		 4 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:93415
Irs1tm1Tka/Irs1tm1Tka   Not Specified J:21373
Irs2tm1Mfw/Irs2tm1Mfw   involves: 129S1/Sv * 129X1/SvJ * C57BL/6J J:46134
Irs2tm1Tka/Irs2tm1Tka   involves: C57BL/6 * CBA J:65485
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0		 4 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:93415
Pdx1tm1Cvw/Pdx1+
Pbx1tm1Mlc/Pbx1+		   involves: 129S6/SvEvTac * C57BL/6 * 129T1/Sv J:75811
Slc2a4tm1Mch/Slc2a4+   involves: 129/Sv * C57BL/6J * CD-1 * SJL J:43650
Models with phenotypic similarity to human disease where etiologies are distinct.2
Ay/a   involves: KK J:26460
Ctf1tm1Msd/Ctf1tm1Msd   B6.Cg-Ctf1tm1Msd J:176727
Cyb5r4tm1Hfb/Cyb5r4tm1Hfb   involves: 129S4/SvJae * BALB/cAnN J:91486
Fem1btm1Jfma/Fem1btm1Jfma   involves: 129X1/SvJ * C57BL/6 J:100017
Htr2ctm1Jul/Y   B6.129S-Htr2ctm1Jul J:50262
Leprbrta/Leprbrta   C57BL/6JSfdAnu-Leprbrta/Apb J:104190
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0		   involves: C3H * C57BL/6 * C57BLKS/J J:186924
Leprdb/Leprdb   C57BLKS/J J:104790
Leprdb/Leprdb   BKS.Cg-Dock7m +/+ Leprdb/J J:185546
LeprTg(Mth11)1Aig/LeprTg(Mth11)1Aig   involves: Him:OF1 J:61119
Mafatm1Staka/Mafatm1Staka   involves: ICR J:99126
Phox2a/Inppl1tm1Ssch/Phox2a+   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:96443
Phox2a/Inppl1tm1Ssch/Phox2a/Inppl1tm1Ssch   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:96443
Ppp1r3atm1Ptwc/Ppp1r3atm1Ptwc   involves: 129P2/OlaHsd * C57BL/6J J:82422
Ppp1r3ctm1Ars/Ppp1r3c+   B6.129-Ppp1r3ctm1Ars J:83297
Slc2a2tm1Thor/Slc2a2tm1Thor   involves: 129P2/OlaHsd * C57BL/6J J:43839
Models involving transgenes or other mutation types.3
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0		   involves: C3H * C57BL/6 * C57BLKS/J J:186924
Tg(aP2-SREBF1c)9884Reh/0   involves: C57BL/6J * SJL J:50770
Tg(APOB)11Rub/0
Tg(UcpDta)1Kz/0		   involves: C57BL/6J * FVB/N J:78211
Tg(Ckm-IGF1R*K1003R)1Dlr/0   FVB/N-Tg(Ckm-IGF1R*K1003R)1Dlr J:71205
Tg(UcpDta)1Kz/?   involves: FVB/N J:78211
Timo/Timo   either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ) J:127183

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory