Human Disease and Mouse Model Detail

Human Disease

Term: Maturity-Onset Diabetes of the Young, Type 2; MODY2
OMIM ID: 125851

Synonyms

Mody, Type 2

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Gck

GCK

...both mouse and human orthologous genes.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background	Ref(s)
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Gck^Gena348/Gck^Gena348		involves: BALB/c * C3H/HeN	J:90389
Gck^Gena348/Gck⁺		involves: BALB/c * C3H/HeN	J:90389
Gck^m1Rge/Gck⁺		involves: C3HeB/FeJ	J:162903
Gck^Rgsc149/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc210/Gck^Rgsc210		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc210/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc236/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc272/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc341/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc392/Gck^Rgsc392		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc392/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc475/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc552/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc553/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc702/Gck^Rgsc702		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc702/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^Rgsc735/Gck⁺		involves: C57BL/6J * DBA/2J	J:88919
Gck^tm1.1Mgn/Gck^tm1.1Mgn Tg(Ins2-cre)25Mgn/0	2	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	J:51826
Gck^tm1.1Mgn/Gck⁺ Tg(Ins2-cre)25Mgn/0	2	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	J:51826
Gck^tm1.1Mgn/Gck^tm1.1Mgn Tg(Alb-cre)21Mgn/0	2	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	J:51826
Gck^tm1.2Mgn/Gck^tm1.2Mgn		involves: 129S6/SvEvTac * C57BL/6	J:51826
Gck^tm1.2Mgn/Gck⁺		involves: 129S6/SvEvTac * C57BL/6	J:51826
Gck^tm1Efr/Gck⁺		involves: 129P2/OlaHsd * C57BL/6	J:28756
Gck^tm1Hrt/Gck⁺ Tg(Alb-cre)21Mgn/0	2	involves: C57BL/6 * DBA	J:105247
Gck^tm1Tka/Gck⁺		involves: 129X1/SvJ * ICR	J:30334
Gck^tm1Ts/Gck^tm1Ts		either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)	J:29255
Gck^tm1Ts/Gck⁺		either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J)	J:29255
Gck^tm2Mgn/Gck^tm2Mgn		129S6/SvEvTac-Gck^tm2Mgn	J:121910
Gck^tm2Mgn/Gck⁺		129S6/SvEvTac-Gck^tm2Mgn	J:121910

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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