Human Disease and Mouse Model Detail

Human Disease

Term: Cataract, Lamellar
OMIM ID: 116800

Synonyms

Cataract, Zonular

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Hsf4

HSF4

...both mouse and human orthologous genes.

Crygb

CRYGB

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Hsf4^ldis1/Hsf4^ldis1		involves: C57BL/6 * CAST/EiJ * RIIIS/J	J:179658
Models with phenotypic similarity to human disease where etiologies are distinct.²
Crygb^Clapper/Crygb⁺		C57BL/6J-Crygb^Clapper	J:100851
Crygb^Clapper/Crygb^Clapper		C57BL/6J-Crygb^Clapper	J:100851

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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