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Human Disease and Mouse Model Detail
Human Disease

Term: Cardiomyopathy, Familial Hypertrophic, 2; CMH2
OMIM ID: 115195

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Tnnt2 TNNT2
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Myh6-Tnnt2)117Lnwd   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Myh6-Tnnt2)191Lnwd
Tg(Myh6-TNNT2*R92Q)#Ajm
Tg(Tnnt2-TNNT2*R92Q)#Ajm
Tg(Tnnt2-TNNT2*R92Q)M-2Ajm

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models involving transgenes or other mutation types.1
Tg(Myh6-Tnnt2)117Lnwd/0   involves: C57BL/6 J:48301
Tg(Myh6-Tnnt2)191Lnwd/0   involves: C57BL/6 J:48301
Tg(Myh6-TNNT2*R92Q)#Ajm/0   involves: C3H * C57BL/6 * ICR J:161899, J:162685
Tg(Tnnt2-TNNT2*R92Q)#Ajm/0   involves: C3H * C57BL/6 * ICR J:117554
Tg(Tnnt2-TNNT2*R92Q)M-2Ajm/0   involves: C3H * C57BL/6 * ICR J:117554

1Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory