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Human Disease and Mouse Model Detail
Human Disease

Term: Hepatocellular Carcinoma
OMIM ID: 114550

Synonyms Cancer, Hepatocellular; HCC; Liver Cancer; Liver Cell Carcinoma; LCC
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Apc APC
  mousehuman...both mouse and human orthologous genes.
     
Abcb4 ABCB4
Cdkn1a CDKN1A
Foxm1 FOXM1
Gtf2ird1 GTF2IRD1
Lect2 LECT2
Mcm9 MCM9
Nfe2l1 NFE2L1
Nr1h4 NR1H4
Pten PTEN
Rb1 RB1
Rbl1 RBL1
Rbl2 RBL2
Txnip TXNIP
Uaca UACA
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Axin1 AXIN1
Casp8 CASP8
Ctnnb1 CTNNB1
Met MET
Pdgfrl PDGFRL
Pik3ca PIK3CA
Trp53 TP53
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tcra-J   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Alb-E2F1)8Sst
Tg(Alb-TAg)1Gjh
Tg(Alb-TAg)#Arnd
Tg(Cebpb-tTA)5Bjd
Tg(MtTGFA)42Lmb
Tg(Myl2-FGF19)1Dfre
Tg(Pklr-Myc)73Ak
Tg(SERPINC1-SV40)A1Pbr
Tg(SERPINC1-SV40)BPbr
Tg(tetO-MET)23Rwng
Tg(tetO-MYC)36aBop

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Apctm2.1Cip/Apctm2.1Cip 4 involves: 129P2/OlaHsd * C57BL/6N J:94721
Models with phenotypic similarity to human disease where etiologies are distinct.2
Abcb4tm1Bor/Abcb4tm1Bor   either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB/N) J:21232
Cdkn1atm1(HBsAg)Xya/Cdkn1a+   either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078
Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya   either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078
Cdkn1atm2(HBx)Xya/Cdkn1a+   either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078
Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya   either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss) J:88078
Foxm1tm1Rhc/Foxm1tm1Rhc   involves: 129X1/SvJ J:89472
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(Alb-E2F1)8Sst/0		   involves: C57BL/6 * CBA J:101128, J:170790
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(MtTGFA)42Lmb/0		   involves: C57BL/6 * CBA * CD-1 J:34434
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0		   B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak J:184496
Mcm9Gt(AW0655)Wtsi/Mcm9Gt(AW0655)Wtsi   involves: 129P2/OlaHsd * C3HeB/FeJ J:177420
Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg   involves: 129P2/OlaHsd * C3HeB/FeJ J:177420
Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg   involves: 129P2/OlaHsd * C3HeB/FeJ J:177420
Nfe2l1tm1Jefc/Nfe2l1tm1Ywk
Tg(Alb-cre)21Mgn/0		 4 involves: 129X1/SvJ * C57BL/6J J:97188
Nr1h4tm1Gonz/Nr1h4tm1Gonz   involves: 129X1/SvJ * C57BL/6N J:121075, J:170790
Nr1h4tm1Gonz/Nr1h4tm1Gonz   involves: 129X1/SvJ * C57BL/6 J:118204, J:170790
Ptentm2Mak/Ptentm2Mak
Tg(Alb-cre)21Mgn/0		 4 involves: 129P2/OlaHsd * C57BL/6 * DBA J:138099
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj		 4 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 J:177573
Rb1tm3Tyj/Rb1tm3Tyj
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0		 4 involves: FVB/N * NMRI J:172430
TxnipHyplip1/TxnipHyplip1   HcB19/Dem-TxnipHyplip1 J:112292
TxnipHyplip1/Txnip+   involves: CAST/Ei * HcB19/Dem J:112292
TxnipHyplip1/TxnipHyplip1   involves: CAST/Ei * HcB19/Dem J:112292
Uacatm1Kiy/Uacatm1Kiy   B6.129P2-Uacatm1Kiy J:157049
Models involving transgenes or other mutation types.3
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(Alb-E2F1)8Sst/0		   involves: C57BL/6 * CBA J:101128, J:170790
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1+
Tg(MtTGFA)42Lmb/0		   involves: C57BL/6 * CBA * CD-1 J:34434
Lect2tm1Ymg/Lect2tm1Ymg
Tg(Pklr-Myc)73Ak/0		   B6.Cg-Lect2tm1Ymg Tg(Pklr-Myc)73Ak J:184496
Rb1tm3Tyj/Rb1tm3Tyj
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0		 4 involves: FVB/N * NMRI J:172430
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0		   B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak J:184496
Tg(Alb-E2F1)8Sst/0   involves: C57BL/6J * CBA/J J:65354, J:101128, J:170790
Tg(Alb-TAg)#Arnd/0 4 C3Fe.Cg-Tg(Alb-TAg)#Arnd J:171880
Tg(Alb-TAg)1Gjh/0   C3.Cg-Tg(Alb-TAg)1Gjh J:105110
Tg(Myl2-FGF19)1Dfre/?   involves: FVB J:77160, J:187236
Tg(Pklr-Myc)73Ak/0   B6.Cg-Tg(Pklr-Myc)73Ak J:184496
Tg(Pklr-Myc)73Ak/0   involves: C57BL/6 * DBA J:185488
Tg(SERPINC1-SV40)A1Pbr/0   involves: C57BL/6 * DBA/2 J:101541
Tg(SERPINC1-SV40)A1Pbr/Tg(SERPINC1-SV40)A1Pbr   involves: C57BL/6 * DBA/2 J:101541
Tg(tetO-MET)23Rwng/0
Tg(Cebpb-tTA)5Bjd/0		   involves: FVB/N * NMRI J:69731
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0		   involves: FVB/N * NMRI J:93899, J:172430
X/Tg(SERPINC1-SV40)BPbr   involves: C57BL/6 * DBA/2 J:84204, J:101541

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory