About   Help   FAQ
Human Disease and Mouse Model Detail
Human Disease

Term: Colorectal Cancer; CRC
OMIM ID: 114500

Synonyms Colon Cancer
Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
Apc APC
  mousehuman...both mouse and human orthologous genes.
     
Il10 IL10
Kras KRAS
Rab25 RAB25
Smad3 SMAD3
Smad4 SMAD4
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Akt1 AKT1
Aurka AURKA
Axin2 AXIN2
Bcl10 BCL10
Bub1b BUB1B
Ccnd1 CCND1
Ctnnb1 CTNNB1
Ep300 EP300
Fgfr3 FGFR3
Flcn FLCN
Mlh3 MLH3
Nras NRAS
Odc1 ODC1
Pdgfrl PDGFRL
Pik3ca PIK3CA
Pla2g2a PLA2G2A
Ptprj PTPRJ
Tlr2 TLR2
Tlr4 TLR4
Trp53 TP53
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Cebpb-tTA)5Bjd   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(MUC1)79.24Gend
Tg(tetO-MYC)36aBop

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Apctm1Ecrm/Apc+
Tg(Fabp1-cre)1Jig/0
4 involves: 129P2/OlaHsd * FVB/N J:159883
Apctm1Mmt/Apc+
Smad4tm1Mmt/Smad4+
  involves: 129S2/SvPas * C57BL/6 J:46242
Apctm2Rak/Apctm2Rak
Krastm4Tyj/Kras+
4 involves: 129 * 129S4/SvJae * C57BL/6J * SJL J:156532
Apctm2Rak/Apctm2Rak 4 involves: 129/Sv * C57BL/6J * SJL J:156532
Models with phenotypic similarity to human disease where etiologies are distinct.2
Il10tm1Cgn/Il10tm1Cgn
Tg(MUC1)79.24Gend/0
  B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend J:149347
Rab25tm1Jrgo/Rab25tm1Jrgo
Smad3tm1Par/Smad3+
  129-Rab25tm1Jrgo Smad3tm1Par J:158733
Models involving transgenes or other mutation types.3
Il10tm1Cgn/Il10tm1Cgn
Tg(MUC1)79.24Gend/0
  B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend J:149347
Tg(tetO-MYC)36aBop/0
Tg(Cebpb-tTA)5Bjd/0
  involves: FVB/N * NMRI J:190067

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/03/2013
MGI 5.12
The Jackson Laboratory