Human Disease and Mouse Model Detail

Human Disease

Term: Breast Cancer
OMIM ID: 114480

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Bard1	BARD1
Brca2	BRCA2
Pik3ca	PIK3CA
Trp53	TP53

...both mouse and human orthologous genes.

Apc	APC
Bin1	BIN1
Brca1	BRCA1
Cav1	CAV1
Eef1a1	EEF1A1
Erbb2	ERBB2
Etv4	ETV4
Fgfr4	FGFR4
Pten	PTEN
Wap	none identified

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Akt1	AKT1
Atm	ATM
Brip1	BRIP1
Casp8	CASP8
Cdh1	CDH1
Chek2	CHEK2
Hmmr	HMMR
Kras	KRAS
Nqo2	NQO2
Palb2	PALB2
Phb	PHB
Ppm1d	PPM1D
Rad51	RAD51
Rad54l	RAD54L
Rb1cc1	RB1CC1
Slc22a18	SLC22A18
Tsg101	TSG101
Xrcc3	XRCC3

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Transgenes and
other mutation types

T(9;17)138Ca		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(CAG-Has2)99Nita
Tg(MMTV-AURKA)#Cxd
Tg(MMTV-ERBB2*,-luc)6157Aami
Tg(MMTV-Myc)141-3Led
Tg(MMTVneu)202Mul
Tg(MMTV-neu/OT-I/OT-II)CBnel
Tg(MMTV-PyVT)634Mul
Tg(MMTV-PyVT*Y250F)250-2Mul
Tg(MMTV-PyVTY315FY322F)Db-1Mul
Tg(MMTV-rtTA)1Lach
Tg(MMTV-TGFBR2)7Hlm
Tg(tetO-Esr1)#Paf
Tg(tetO-IGF1R)1Ramo
Tg(tetO-MYC)1Lach
Tg(Trp53R172H)8512Jmr
Tg(Wap-TAg)1Depp
Tg(Wap-TAg)NP8Depp
Tg(WapTgfa)215Bri
Tg(Wnt1)1Hev

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background	Ref(s)
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Apc^Min/Apc⁺ Brca2^tm1Mbn/Brca2⁺		B6.Cg-Brca2^tm1Mbn Apc^Min	J:67445
Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	4	involves: 129S1/Sv * C57BL/6J	J:134977
Bard1^tm2Thl/Bard1^tm2Thl Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	4	involves: 129/Sv * 129S1/Sv * C57BL/6J	J:134977
Bard1^tm2Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	4	involves: 129/Sv * 129S1/Sv * C57BL/6J	J:123977
Brca1^tm1Brn/Brca1^tm1.1Jjon Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	J:178595
Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	J:126551
Brca1^tm1Brn/Brca1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	J:126551
Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	J:126551
Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	J:178595
Brca2^tm1Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap⁺	4	involves: 129S/SvEv * C57BL/6	J:70564
Brca2^tm1Brn/Brca2^tm1Brn Trp53^tm1Brn/Trp53^tm1Brn Tg(KRT14-cre)8Brn/0	4	involves: 129P2/OlaHsd * FVB/N	J:73028
Brca2^tm1Mbn/Brca2⁺		B6.Cg-Brca2^tm1Mbn Apc^Min	J:67445
Brca2^tm1Mhun/Brca2⁺		involves: 129S7/SvEvBrd * C57BL/6J	J:89083
Brca2^tm2Arge/Brca2^tm2Arge Wap^tm1(cre)Arge/Wap^tm1(cre)Arge	4	involves: 129S1/Sv * C57BL/6	J:70564
Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺ Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)4Mam/0	4	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB	J:170898
Pik3ca^tm1Gne/Pik3ca⁺ Tg(MMTV-cre)1Mam/0	4	involves: C57BL/6N * FVB	J:193377
Tg(MMTV-AURKA)#Cxd/? Trp53^tm1Tyj/Trp53⁺		involves: 129S2/SvPas * FVB/N	J:145680
Models with phenotypic similarity to human disease where etiologies are distinct.²
Bin1^tm1Gcp/Bin1^tm2Gcp Tg(MMTV-Myc)141-3Led/0 Tg(Wap-cre)11738Mam/0	4	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	J:117730
Brca1^tm1Aash/Brca1^tm1Aash Tg(LGB-cre)74Acl/0	4	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	J:119996
Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0	4	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	J:134977
Brca1^tm1Thl/Brca1^tm1Thl Wap^tm1(cre)Arge/0	4	involves: 129S1/Sv * C57BL/6J	J:134977
Cav1^tm1Mls/Cav1^tm1Mls		involves: 129/Sv * C57BL/6 * FVB/N * SJL	J:147439
Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺	4	involves: 129S1/Sv	J:146290
Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)7Mul/0	4	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	J:133305
Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Pten^tm1Hwu/Pten⁺ Tg(MMTV-cre)7Mul/0	4	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N	J:133305
Erbb2^{tm8(Erbb2)Mul}/Erbb2⁺ Tg(MMTV-cre)7Mul/?	4	involves: 129S1/Sv * 129X1/SvJ * FVB/N	J:167180
Etv4^tm1Hass/Etv4^tm1Hass Tg(MMTVneu)202Mul/Tg(MMTVneu)202Mul		involves: FVB/N	J:87017
Fgfr4^tm1Axul/Fgfr4^tm1Axul Tg(WapTgfa)215Bri/0		B6.Cg-Fgfr4^tm1Axul Tg(WapTgfa)215Bri	J:156750
Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)4Mam/0	4	involves: 129S6/SvEvTac * FVB	J:170898
Pten^tm1Rps/Pten⁺ Tg(Wnt1)1Hev/0		involves: 129S1/Sv * C57BL/6 * FVB * SJL	J:67497
Models involving transgenes or other mutation types.³
Bin1^tm1Gcp/Bin1^tm2Gcp Tg(MMTV-Myc)141-3Led/0 Tg(Wap-cre)11738Mam/0	4	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	J:117730
Etv4^tm1Hass/Etv4^tm1Hass Tg(MMTVneu)202Mul/Tg(MMTVneu)202Mul		involves: FVB/N	J:87017
Fgfr4^tm1Axul/Fgfr4^tm1Axul Tg(WapTgfa)215Bri/0		B6.Cg-Fgfr4^tm1Axul Tg(WapTgfa)215Bri	J:156750
Pten^tm1Rps/Pten⁺ Tg(Wnt1)1Hev/0		involves: 129S1/Sv * C57BL/6 * FVB * SJL	J:67497
T(9;17)138Ca/T(9;17)138Ca		Not Specified	J:169366
Tg(CAG-Has2)99Nita/0 Tg(MMTV-cre)4Mam/0 Tg(MMTVneu)202Mul/0	4	FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul	J:164205
Tg(MMTV-AURKA)#Cxd/? Trp53^tm1Tyj/Trp53⁺		involves: 129S2/SvPas * FVB/N	J:145680
Tg(MMTV-AURKA)#Cxd/?		involves: FVB/N	J:145680
Tg(MMTV-ERBB2*,-luc)6157Aami/0		FVB-Tg(MMTV-ERBB2*,-luc)6157Aami	J:172352
Tg(MMTV-neu/OT-I/OT-II)CBnel/?		involves: C57BL/6	J:122846
Tg(MMTV-neu/OT-I/OT-II)CBnel/? Tg(Trp53R172H)8512Jmr/?		involves: C57BL/6 * FVB	J:122846
Tg(MMTV-PyVT)634Mul/0		FVB/N-Tg(MMTV-PyVT)634Mul	J:46460
Tg(MMTV-PyVT*Y250F)250-2Mul/?		FVB/N-Tg(MMTV-PyVT*Y250F)250-2Mul	J:56327
Tg(MMTV-PyVTY315FY322F)Db-1Mul/?		FVB/N-Tg(MMTV-PyVTY315FY322F)Db-1Mul	J:56327
Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Esr1)#Paf/0		involves: FVB/N	J:96383
Tg(MMTV-rtTA)1Lach/0 Tg(tetO-MYC)1Lach/0		involves: FVB	J:67498
Tg(MMTV-rtTA)1Lach/0 Tg(tetO-IGF1R)1Ramo/0		involves: FVB	J:121069
Tg(MMTV-TGFBR2)7Hlm/Tg(MMTV-TGFBR2)7Hlm		involves: C57BL/6 * DBA	J:85799
Tg(MMTVneu)202Mul/0		involves: FVB/N	J:80974
Tg(MMTVneu)202Mul/0		FVB/N-Tg(MMTVneu)202Mul	J:56332
Tg(Trp53R172H)8512Jmr/0		involves: FVB	J:46246
Tg(Wap-TAg)1Depp/0		involves: BALB/c * C57BL/6	J:61012
Tg(Wap-TAg)NP8Depp/0		involves: BALB/c * C57BL/6	J:61012
Tg(Wnt1)1Hev/0		involves: C57BL/6 * SJL	J:61009

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
³Models involving transgenes or other mutation types may also appear in other sections of the table.
⁴Conditionally targeted allele(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2013 MGI 5.12