Human Disease and Mouse Model Detail

Human Disease

Term: Burkitt Lymphoma; BL
OMIM ID: 113970

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Myc

MYC

...both mouse and human orthologous genes.

Transgenes and
other mutation types

Igh		Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(IghMyc)22Bri
Tg(IGL-MYC)3Hm

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Myc^tm1Lbox/Myc^tm1Lbox		involves: 129S1/Sv * 129X1/SvJ * FVB/N	J:97900
Myc^tm1Lbox/Myc⁺		involves: 129S1/Sv * 129X1/SvJ * FVB/N	J:97900
Models involving transgenes or other mutation types.²
Igh^tm1(Myc)Janz/Igh⁺		involves: 129X1/SvJ * C57BL/6	J:96785
Tg(IghMyc)22Bri/0		involves: C57BL/6 * SJL	J:78177, J:186117
Tg(IGL-MYC)3Hm/0		C57BL/6N-Tg(IGL-MYC)3Hm	J:65245

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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