Human Disease and Mouse Model Detail

Human Disease

Term: Autoimmune Disease
OMIM ID: 109100

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Axl	AXL
Cd200	CD200
Gpr132	GPR132
Mertk	MERTK
Tyro3	TYRO3

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.¹
Axl^tm1Grl/Axl^tm1Grl Mertk^tm1Grl/Mertk^tm1Grl Tyro3^tm1Grl/Tyro3^tm1Grl		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	J:70420
Cd200^tm1Jods/Cd200^tm1Jods		C57BL/6-Cd200^tm1Jods	J:65982
Gpr132^tm1Witt/Gpr132^tm1Witt		involves: 129X1/SvJ * BALB/c	J:69473

¹The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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