Human Disease and Mouse Model Detail

Human Disease

Term: Apolipoprotein E; APOE
OMIM ID: 107741

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Apoe

APOE

...both mouse and human orthologous genes.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Apoe^shl/Apoe^shl		involves: C3H/He * KOR	J:54051
Apoe^shl/Apoe^shl		involves: C57BL/6 * KOR	J:54051
Apoe^shl/Apoe^shl		involves: BALB/c * KOR	J:54051
Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae}		involves: 129P2/OlaHsd * C57BL/6	J:48565
Apoe^tm1Lmh/Apoe⁺		involves: 129S7/SvEvBrd * C57BL/6	J:22347
Apoe^tm1Lmh/Apoe^tm1Lmh		involves: 129S7/SvEvBrd * C57BL/6	J:22347
Apoe^tm1Unc/Apoe^tm1Unc		involves: 129P2/OlaHsd * C57BL/6	J:16573

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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