Human Disease and Mouse Model Detail

Human Disease

Term: Apolipoprotein B; APOB
OMIM ID: 107730

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Apob

APOB

...both mouse and human orthologous genes.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Apob^tm1.1Zc/Apob^tm1.1Zc		involves: 129X1/SvJ * C57BL/6	J:65191
Apob^tm1Unc/Apob^tm1Unc		involves: 129P2/OlaHsd * C57BL/6J	J:16352
Apob^tm1Unc/Apob⁺		involves: 129P2/OlaHsd * C57BL/6J	J:16352
Apob^tm1Zc/Apob^tm1.1Zc		involves: 129/Sv * C57BL/6	J:76047
Apob^tm1Zc/Apob⁺		involves: 129/Sv * C57BL/6	J:76047
Apob^tm1Zc/Apob^tm1Zc		involves: 129/Sv * C57BL/6	J:76047
Apob^tm2Sgy/Apob^tm4Sgy		involves: 129/Sv * 129S4/SvJae * C57BL/6	J:46549
Apob^tm5Sgy/Apob^tm5Sgy		involves: 129S4/SvJae * C57BL/6	J:51549

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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