Human Disease and Mouse Model Detail

Human Disease

Term: Tooth Agenesis, Selective, 1; STHAG1
OMIM ID: 106600

Synonyms

Hypodontia/Oligodontia 1; HYD1; Second Premolars and Third Molars, Absence of

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Msx1

MSX1

...both mouse and human orthologous genes.

Msx2

MSX2

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Msx1^tm1Bero/Msx1^tm1Bero		B6.129P2-Msx1^tm1Bero	J:42035
Msx1^tm1Rilm/Msx1^tm1Rilm		either: (involves: 129S4/SvJae-Msx1^tm1Rilm) or (involves: 129S4/SvJae * BALB/c) or (involves: 129X1/SvJae * C57BL/6J)	J:17489
Msx1^tm1Rilm/Msx1^tm1Rilm Msx2^tm1Rilm/Msx2^tm1Rilm		involves: BALB/c * CD-1	J:61509

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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