About   Help   FAQ
Human Disease and Mouse Model Detail
Human Disease

Term: Alzheimer Disease; AD
OMIM ID: 104300

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
App APP
Plau PLAU
Sorl1 SORL1
  mousehuman...both mouse and human orthologous genes.
     
Abcc1 ABCC1
Apoa4 APOA4
Apoe APOE
Cav1 CAV1
Clu CLU
Hprt HPRT1
Klc1 KLC1
Ldlr LDLR
Lepr LEPR
Lrp1 LRP1
Mapt MAPT
Mme MME
Msr1 MSR1
Nos2 NOS2
Npc1 NPC1
Pin1 PIN1
Plcb1 PLCB1
Ppp3ca PPP3CA
Psen1 PSEN1
Psen2 PSEN2
Trib2 TRIB2
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
A2m A2M
Ace ACE
Apbb2 APBB2
Blmh BLMH
Hfe HFE
Mpo MPO
Nos3 NOS3
Paxip1 PAXIP1
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(ACTB-APP*V717F)1Colm   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(APP695)3Dbo
Tg(APP)8.9Btla
Tg(APPSw)40Btla
Tg(APPSWE)2576Kha
Tg(APPswe,PSEN1dE9)85Dbo
Tg(APPSwe,tauP301L)1Lfa
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Tg(APPSwLon)96Btla
Tg(APPV717F)109Ili
Tg(Camk2a-App*,-Apbb1)25Spim
Tg(Camk2a-tTA)1Mmay
Tg(DMD-APP*)18Neve
Tg(DMD-APP*)7Neve
Tg(Eno2-PSEN2*)1480Ykk
Tg(Eno2-PSEN2)2348Ykk
Tg(Gfap-TGFB1)64Lms
Tg(GFAP-tTA)#Hyms
Tg(GSK3B*S9A)1Vln
Tg(Hmgcr-PSEN1*M146L)#Lpr
Tg(MAPT)8cPdav
Tg(Mapt-MAPT*)#Hanr
Tg(PDGFB-APPSwDutLon)46Lpr
Tg(PDGFB-APPSwInd)20Lms
Tg(PDGFB-APPSwInd)J9Lms
Tg(PDGFB-PSEN1M146L)2Jhd
Tg(Prnp-APP*)1Hmor
Tg(Prnp-APP)A-2Dbo
Tg(Prnp-App/APPswe)E1-2Dbo
Tg(PRNP-APPSweInd)8Dwst
Tg(Prnp-ITM2B/APP695*40)1Emcg
Tg(Prnp-ITM2B/APP695*42)A12Emcg
Tg(Prnp-MAPT)43Vle
Tg(Prnp-MAPT*P301L)JNPL3Hlmc
Tg(PSEN1)5Dbo
Tg(PSEN1dE9)S9Dbo
Tg(PSEN1H163R)G9Btla
Tg(tetO-APPSwInd)102Dbo
Tg(tetO-APPSwInd)107Dbo
Tg(tetO-APPSwInd)18Dbo
Tg(tetO-HMOX1)#Hyms
Tg(tetO-MAPT*P301L)#Kha
Tg(Thy1-APP*)2.2Ingm
Tg(Thy1-APP)3Somm
Tg(Thy1-APPArc)M8Cagr
Tg(Thy1-APPLon)2Vln
Tg(Thy1-APP)28Lpr
Tg(Thy1-APPSw)10Jiri
Tg(Thy1-APPSwDutIowa)BWevn
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Tg(Thy1-BACE1)16Vln
Tg(Thy1-MAPT)183Gotz
Tg(Thy1-MAPT)1Vln
Tg(Thy1-MAPT)22Schd
Tg(Thy1-MAPT)2Vln
Tg(Thy1-MAPT*P301L)2Vln
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte

Mouse Models
Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.1
Apptm1.1Cep/App+   involves: 129S1/Sv * 129X1/SvJ J:35500
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf		   involves: 129S1/Sv * 129X1/SvJ * CD-1 J:102425
Apptm1.1Cep/Apptm1.1Cep   involves: 129S1/Sv * 129X1/SvJ J:35500
Apptm1Cep/Apptm1Cep   involves: 129S1/Sv * 129X1/SvJ J:35500
Apptm1Cep/App+   involves: 129S1/Sv * 129X1/SvJ J:35500
Apptm1Dbo/Apptm1Dbo
Npc1m1N/Npc1m1N		   C.Cg-Apptm1Dbo Npc1m1N J:172769
Apptm1Dbo/Apptm1Dbo   involves: 129S7/SvEvBrd * C57BL/6J J:53824
Apptm1Ini/App+   involves: C57BL/6 * CBA * CD-1 J:90296
Plautm1Mlg/Plautm1Mlg   involves: 129S2/SvPas * C57BL/6 J:104962
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0		   involves: 129 * C3H/HeJ * C57BL/6 J:142501
Models with phenotypic similarity to human disease where etiologies are distinct.2
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0		   FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr J:178230
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?		   involves: 129S4/SvJae * C57BL/6 * SJL J:169682
Apoetm1Unc/Apoetm1Unc
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129P2/OlaHsd * 129S2/SvPas J:107702
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129P2/OlaHsd J:107702
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(Thy1-APPSwDutIowa)BWevn/?		   involves: 129P2/OlaHsd * C57BL/6 J:136318
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(APPSWE)2576Kha/?		   involves: 129P2/OlaHsd * C57BL/6 * SJL J:98636
Cav1tm1Mls/Cav1tm1Mls   Not Specified J:168335
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129S2/SvPas J:78357
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0		   involves: 129P2/OlaHsd J:180977
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?		   involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 J:96346
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0		   involves: 129S7/SvEvBrd * C57BL/6 * SJL J:114480
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0		   involves: C3H * C57BL/6 * C57BLKS/J J:186924
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0		 5 involves: 129S7/SvEvBrd * BALB/c * C57BL J:167724
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?		   involves: 129S4/SvJae * C57BL/6 * Swiss Webster J:84638, J:174270
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0		   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J J:172426
Mmetm1Cge/Mmetm1Cge   involves: 129S4/SvJae * C57BL/6 J:69830
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?		   involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR J:58338
Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0		   involves: 129P2/OlaHsd * C57BL/6 * SJL J:112919
Npc1m1N/Npc1m1N
Tg(PRNP-APPSweInd)8Dwst/0		   involves: BALB/c * C3H/HeJ * C57BL/6J J:188345
Pin1tm1Tuc/Pin1tm1Tuc
Tg(APPSWE)2576Kha/0		   involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL J:107132
Pin1tm1Tuc/Pin1tm1Tuc   involves: 129 * 129P2/OlaHsd * C57BL/6 J:107132
Plcb1tm1Hssh/Plcb1tm1Hssh   Not Specified J:43077
Ppp3catm1Jse/Ppp3catm1Jse   either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6) J:39103
Psen1tm1Bdes/Psen1tm1Bdes   involves: 129P2/OlaHsd J:71037
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?		   involves: 129 * C57BL/6 * CD-1 * SJL J:102425
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0		 5 involves: C57BL/6 * CBA J:73252
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0		 5 involves: C57BL/6 * CBA J:90685
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0		   either: 129/Sv or (involves: 129/Sv * C57BL/6) J:93770
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0		   involves: 129 * C57BL/6 * CBA J:128106
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa		   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:99604
Psen1tm1Mpm/Psen1tm1Mpm   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:51950
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?		   B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa J:170670
Psen1tm1Mpm/Psen1tm1Pcw   involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 J:91277
Psen1tm1Shn/Psen1tm1Shn   involves: 129S7/SvEvBrd * C57BL/6 J:40365
Psen1tm1Tak/Psen1tm1Tak   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:99353
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0		 5 involves: FVB/N J:87229
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?		   involves: 129S7/SvEvBrd * C57BL/6 * SJL J:107251
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0		   involves: C57BL/6 * DBA/1 J:176575
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2Tg(Thy1-Trh/APP*)2.1Ingm   involves: C57BL/6 * DBA/1 J:176575
Models involving transgenes or other mutation types.3
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0		   FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr J:178230
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?		   involves: 129S4/SvJae * C57BL/6 * SJL J:169682
Apoetm1Unc/Apoetm1Unc
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129P2/OlaHsd * 129S2/SvPas J:107702
Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129P2/OlaHsd J:107702
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(Thy1-APPSwDutIowa)BWevn/?		   involves: 129P2/OlaHsd * C57BL/6 J:136318
Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae
Tg(APPSWE)2576Kha/?		   involves: 129P2/OlaHsd * C57BL/6 * SJL J:98636
Clutm1Jakh/Clutm1Jakh
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili		   involves: 129S2/SvPas J:78357
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0		   involves: 129P2/OlaHsd J:180977
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?		   involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 J:96346
Ldlrtm1Her/Ldlrtm1Her
Tg(APPSWE)2576Kha/0		   involves: 129S7/SvEvBrd * C57BL/6 * SJL J:114480
Leprdb/Lepr+
Tg(APPswe,PSEN1dE9)85Dbo/0		   involves: C3H * C57BL/6 * C57BLKS/J J:186924
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0		   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J J:172426
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?		   involves: 129S4/SvJae * C57BL/6 * Swiss Webster J:84638, J:174270
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?		   involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR J:58338
Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0		   involves: 129P2/OlaHsd * C57BL/6 * SJL J:112919
Npc1m1N/Npc1m1N
Tg(PRNP-APPSweInd)8Dwst/0		   involves: BALB/c * C3H/HeJ * C57BL/6J J:188345
Pin1tm1Tuc/Pin1tm1Tuc
Tg(APPSWE)2576Kha/0		   involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL J:107132
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?		   involves: 129 * C57BL/6 * CD-1 * SJL J:102425
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0		   involves: 129 * C57BL/6 * CBA J:128106
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0		   either: 129/Sv or (involves: 129/Sv * C57BL/6) J:93770
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?		   B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa J:170670
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa		   involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:99604
Psen1tm1Zhe/Psen1tm1Zhe
Tg(APPSWE)2576Kha/?		   involves: 129S7/SvEvBrd * C57BL/6 * SJL J:107251
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0		   involves: 129 * C3H/HeJ * C57BL/6 J:142501
Tg(ACTB-APP*V717F)1Colm/0   involves: C57BL/6 * DBA J:157859
Tg(APP)8.9Btla/Tg(APP)8.9Btla   involves: 129S2/SvPas J:96742
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0		   involves: C3H/HeJ * C57BL/6J J:123534
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0		   involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J J:123534
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0		   involves: C3H/HeJ * C57BL/6J J:43788
Tg(APP695)3Dbo/0   involves: C3H/HeJ * C57BL/6J J:87691
Tg(APP695)3Dbo/0   B6.C3-Tg(APP695)3Dbo J:109847
Tg(APPSw)40Btla/Tg(APPSw)40Btla   B6.129-Tg(APPSw)40Btla J:86629
Tg(APPSw)40Btla/0   involves: 129S1/Sv * 129X1/SvJ J:42613
Tg(APPSWE)2576Kha/0   involves: C57BL/6 * SJL J:119251
Tg(APPSWE)2576Kha/0   involves: 129S7/SvEvBrd * C57BL/6 * SJL J:114480, J:180385
Tg(APPSWE)2576Kha/0
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0		   involves: C57BL/6 * DBA/2 * SJL * SW J:100965
Tg(APPSWE)2576Kha/0
Tg(PDGFB-PSEN1M146L)2Jhd/0		   involves: C57BL/6 * DBA/2 * SJL * SW J:174270
Tg(APPSWE)2576Kha/0
Tg(PSEN1)5Dbo/0		   involves: C57BL/6 * SJL J:191088
Tg(APPSWE)2576Kha/0   involves: C57BL/6 * DBA/2 * SJL * SW J:174270
Tg(APPswe,PSEN1dE9)85Dbo/0   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax J:160557, J:172426
Tg(APPswe,PSEN1dE9)85Dbo/0   B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax J:113199
Tg(APPswe,PSEN1dE9)85Dbo/0   involves: C3H/HeJ * C57BL/6J J:87691, J:113200
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?   involves: 129S4/SvJae * C57BL/6 * SJL J:169682
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0   involves: C57BL/6 * SJL J:112949
Tg(APPSwLon)96Btla/0   involves: 129S4/SvJae J:42613
Tg(APPV717F)109Ili/0   involves: BALB/c * C57BL * C57BL/6NTac J:184975
Tg(APPV717F)109Ili/0   Not Specified J:23080
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili   Not Specified J:78357
Tg(Camk2a-App*,-Apbb1)25Spim/0   C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim J:153738
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0		   involves: C3H/HeJ * C57BL/6 * CBA J:109829
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)107Dbo/0		   involves: C3H/HeJ * C57BL/6 * CBA J:109829
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0		   involves: C3H/HeJ * C57BL/6 * CBA J:109829
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-MAPT*P301L)#Kha/?		   involves: 129S6/SvEvTac * FVB/N J:99626
Tg(DMD-APP*)18Neve/0   involves: C57BL/6 * SJL J:100978
Tg(DMD-APP*)7Neve/0   involves: C57BL/6 * SJL J:100978, J:105050
Tg(Eno2-PSEN2)2348Ykk/0   involves: C57BL/6 * DBA/2 J:76934
Tg(Eno2-PSEN2*)1480Ykk/0   involves: C57BL/6 * DBA/2 J:76934
Tg(Gfap-TGFB1)64Lms/0
Tg(PDGFB-APPSwInd)20Lms/0		   involves: BALB/c * C57BL/6 * DBA/2 * SJL J:167619
Tg(GFAP-tTA)#Hyms/0
Tg(tetO-HMOX1)#Hyms/0		   involves: FVB J:190573
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln		   involves: FVB J:100971
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln		   involves: FVB J:100971
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(PDGFB-APPSwDutLon)46Lpr/0		   involves: C57BL/6 * CBA J:86694
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0		   involves: C57BL/6 * CBA J:86694, J:99507
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0		   involves: C57BL/6 * CBA * FVB/N J:86694
Tg(Mapt-MAPT*)#Hanr/0   involves: BALB/c * C57BL/6 J:137947
Tg(PDGFB-APPSwDutLon)46Lpr/0   involves: C57BL/6 * CBA J:86694
Tg(PDGFB-APPSwInd)20Lms/0   involves: C57BL/6 * DBA/2 J:62290
Tg(PDGFB-APPSwInd)J9Lms/0   involves: C57BL/6 * DBA/2 J:62290
Tg(Prnp-App/APPswe)E1-2Dbo/0   B6.C3-Tg(Prnp-App/APPswe)E1-2Dbo J:109847
Tg(Prnp-APP)A-2Dbo/0   B6.Cg-Tg(Prnp-APP)A-2Dbo/J J:117538
Tg(Prnp-APP*)1Hmor/0   B6.Cg-Tg(Prnp-APP*)1Hmor J:159623
Tg(PRNP-APPSweInd)8Dwst/?   involves: 129S6/SvEvTac J:113199
Tg(PRNP-APPSweInd)8Dwst/0   involves: C3H/HeJ * C57BL/6J J:166801
Tg(Prnp-ITM2B/APP695*42)A12Emcg/0   involves: C3H * C57BL/6 J:101023
Tg(Prnp-ITM2B/APP695*40)1Emcg/0   involves: C3H * C57BL/6 J:101023
Tg(Prnp-MAPT)43Vle/0   involves: C57BL/6 * DBA/2 J:61052
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0   involves: C57BL/6 * DBA/2 * SJL * SW J:100965
Tg(PSEN1dE9)S9Dbo/0   involves: C3H/HeJ * C57BL/6J J:104147
Tg(PSEN1H163R)G9Btla/0   involves: 129S4/SvJae J:58050
Tg(tetO-APPSwInd)102Dbo/0   involves: C3H/HeJ * C57BL/6J J:109829
Tg(Thy1-APP)3Somm/0   B6.Cg-Tg(Thy1-APP)3Somm J:80449
Tg(Thy1-APP)3Somm/0   involves: C57BL/6J * DBA/2 J:44603
Tg(Thy1-APPSL)28Lpr/0   involves: C57BL/6 * CBA J:86694, J:99507
Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr   involves: C57BL/6 * CBA J:188191
Tg(Thy1-APPArc)M8Cagr/0   involves: C57BL/6 * CBA J:168288
Tg(Thy1-APPLon)2Vln/0   involves: C57BL/6 * CBA * FVB/N J:86694
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-BACE1)16Vln/0		   involves: C57BL/6 * DBA * FVB/N J:93635
Tg(Thy1-APPLon)2Vln/0   involves: FVB/N J:93635
Tg(Thy1-APPSw)10Jiri/0   involves: C3H * C57BL/6 J:128647
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0   C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr J:180835
Tg(Thy1-APPSwDutIowa)BWevn/0   involves: C57BL/6 J:89848
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0		   B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz J:154968
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln   involves: FVB J:100971, J:100972
Tg(Thy1-MAPT)22Schd/0   B6.Cg-Tg(Thy1-MAPT)22Schd J:111982
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln   involves: FVB J:100971, J:100972
Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln   FVB/N-Tg(Thy1-MAPT*P301L)2Vln J:96869
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte   involves: C57BL/6 * CBA J:155410
Trib2Tg(Thy1-Trh/APP*)2.1Ingm/Trib2+
Tg(Thy1-APP*)2.2Ingm/0		   involves: C57BL/6 * DBA/1 J:176575
No similarity to the expected human disease phenotype was found.4
NOT Apba2tm1Tsuz/Apba2tm1Tsuz   C57BL/6-Apba2tm1Tsuz J:148481
NOT Mapttm1Noh/Mapttm1Noh   involves: 129S4/SvJae J:19030
NOT Psen1tm1Psgh/Psen1tm1Psgh   Not Specified J:66016

1Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
2Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
3Models involving transgenes or other mutation types may also appear in other sections of the table.
4One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.
5Conditionally targeted allele(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
04/03/2013
MGI 5.12 		The Jackson Laboratory