Human Disease and Mouse Model Detail

Human Disease

Term: Pituitary Adenoma, Growth Hormone-Secreting
OMIM ID: 102200

Synonyms

Isolated Familial Somatotropinoma; IFS; Somatotrophinoma, Familial; Somatotropinoma, Familial Isolated; FIS

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Men1

MEN1

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Aip	AIP
Gnas	GNAS
Sstr5	SSTR5

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype				Ref(s)
Allelic Composition		Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.¹
Men1^tm1Zqw/Men1⁺			involves: 129/Sv * 129P2/OlaHsd	J:85302
No similarity to the expected human disease phenotype was found.²
NOT	Fbn1^Tsk/Fbn1⁺		B10.D2/(58N)Sn	J:5629

¹Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
²One or more human genes are associated with this human disease. The mouse genotype may involve mutations to orthologs of one or more of those genes, but the phenotype did not resemble the disease.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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