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Human Disease and Mouse Model Detail
Human Disease

Term: Leukemia, Acute Lymphoblastic; ALL
OMIM ID: 613065

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Ezh2 EZH2
Ikzf1 IKZF1
Mll1 MLL
Pten PTEN
Zfp36l1 ZFP36L1
Zfp36l2 ZFP36L2
  mouse...the mouse gene.
     OMIM data currently do not associate this disease with the orthologous human gene.
     
Bcr BCR
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(BCR/ABL)623Hkp   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(CD2-Lmo2)#Thr
Tg(Lck-LMO1)11Sjk
Tg(Lck-Notch3)#Issc
Tg(STIL-TAL1)A5(3)Alpa

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models with phenotypic similarity to human disease where etiologies are distinct.1
Ezh2tm2Sho/Ezh2tm2.1Sho
Tg(Mx1-cre)1Cgn/0
3 involves: 129S1/Sv * C57BL/6 * CBA J:182211
Ezh2tm2Sho/Ezh2tm2Sho
Tg(Mx1-cre)1Cgn/0
3 involves: 129S1/Sv * C57BL/6 * CBA J:182211
Ikzf1tm1Kast/Ikzf1+
Tg(BCR/ABL)623Hkp/0
  involves: 129S2/SvPas * C57BL/6 * CBA J:160846
Mll1tm1Saam/Mll1+
Tg(Mx1-cre)1Cgn/0
3 involves: 129S1/Sv * C57BL/6 * CBA J:140628
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
3 involves: 129S4/SvJae * C57BL/6 * CBA J:169097
Tg(CD2-cre)4Kio/0
Zfp36l1tm1.1Tnr/Zfp36l1tm1.1Tnr
Zfp36l2tm1.1Tnr/Zfp36l2tm1.1Tnr
3 involves: C57BL/6 * C57BL/10 * CBA/Ca * SJL J:162388
Models involving transgenes or other mutation types.2
Ikzf1tm1Kast/Ikzf1+
Tg(BCR/ABL)623Hkp/0
  involves: 129S2/SvPas * C57BL/6 * CBA J:160846
Tg(CD2-Lmo2)#Thr/0   involves: C57BL/6 * CBA J:102058
Tg(Lck-LMO1)11Sjk/0
Tg(STIL-TAL1)A5(3)Alpa/0
  involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros J:40868
Tg(Lck-Notch3)#Issc/0   involves: C57BL/6 * DBA/2 J:63300

1Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.
2Models involving transgenes or other mutation types may also appear in other sections of the table.
3Conditionally targeted allele(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory