Human Disease and Mouse Model Detail

Human Disease

Term: Inflammatory Bowel Disease 12; IBD12
OMIM ID: 612241

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Gnai2

GNAI2

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Mouse Models

Genotype				Ref(s)
Allelic Composition		Note	Genetic Background
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.¹
Gnai2^tm1Lbi/Gnai2^tm1Lbi			involves: 129S7/SvEvBrd	J:30507
Gnai2^tm1Uru/Gnai2^tm1Uru			129S/SvEv	J:24434
Gnai2^tm1Uru/Gnai2^tm1Uru			involves: 129S7/SvEvBrd * C57BL/6J	J:24434
Gnai2^tm1Uru/Gnai2^tm1Uru			involves: 129S7/SvEvBrd * C57BL/6	J:91100
No similarity to the expected human disease phenotype was found.²
NOT	Gnai2^tm1Uru/Gnai2^tm1Uru		129X1Bom.129S7-Gnai2^tm1Uru	J:91100

¹The causal human genes for this disease have not been identified. Genotypes may include cases where the mouse structural gene or the human ortholog has not been identified.
²The mouse gene may involve mutations to orthologs of human genes which may be causal in humans, but the phenotype did not resemble the disease.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/03/2013 MGI 5.12