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Human Disease and Mouse Model Detail
Human Disease

Term: Amyotrophic Lateral Sclerosis 10, with or without Frontotemporal Dementia;
OMIM ID: 612069

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene
Human Gene
 
Characteristics of this human disease are associated with mutations in...
     
Tardbp TARDBP
  human...the human gene.
     MGI data currently do not associate this disease with mutations in the orthologous mouse gene.
     
Transgenes and
other mutation types
Tg(Camk2a-tTA)1Mmay   Characteristics of this human disease are associated with transgenes and other mutation types in mouse.
Tg(Prnp-TARDBP)3cPtrc
Tg(Prnp-TARDBP)4Jlel
Tg(Prnp-TARDBP*A315T)23Jlel
Tg(Prnp-TARDBP*A315T)95Balo
Tg(tetO-TARDBP)12Vle
Tg(tetO-TARDBP*)4Vle

Mouse Models

Genotype Ref(s)
Allelic Composition Note Genetic Background
Models involving transgenes or other mutation types.1
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP)12Vle/0
  involves: C3H/HeJ * C57BL/6J J:170756
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-TARDBP*)4Vle/0
  involves: C3H/HeJ * C57BL/6J J:170756
Tg(Prnp-TARDBP)3cPtrc/Tg(Prnp-TARDBP)3cPtrc   C57BL/6-Tg(Prnp-TARDBP)3cPtrc J:163231
Tg(Prnp-TARDBP)4Jlel/0   involves: C57BL/6 * CD-1 * SJL J:165985
Tg(Prnp-TARDBP*A315T)23Jlel/0   involves: C57BL/6 * CD-1 * SJL J:165985
Tg(Prnp-TARDBP*A315T)95Balo/0   involves: C57BL/6 * CBA J:153197

1Models involving transgenes or other mutation types may also appear in other sections of the table.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2013
MGI 5.12
The Jackson Laboratory