Human Disease and Mouse Model Detail

Human Disease

Term: Malaria, Susceptibility to
OMIM ID: 611162

Associated Genes

Orthologous mouse and human markers where mutations in one or both species have been associated with phenotypes characteristic of this disease.

Mouse Gene

Human Gene

Characteristics of this human disease are associated with mutations in...

Fcgr2b	FCGR2B
Icam1	ICAM1

...both mouse and human orthologous genes.

Ank1	ANK1
Hmox1	HMOX1
Ifng	IFNG
Pklr	PKLR

...the mouse gene.
OMIM data currently do not associate this disease with the orthologous human gene.

Cd36	CD36
Cish	CISH
Darc	DARC
Gypc	GYPC
Nos2	NOS2
Slc4a1	SLC4A1
Tirap	TIRAP
Tnf	TNF

...the human gene.
MGI data currently do not associate this disease with mutations in the orthologous mouse gene.

Mouse Models

Genotype			Ref(s)
Allelic Composition	Note	Genetic Background
Models with phenotypic similarity to human disease where etiologies involve orthologs.¹
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk		C.129S4-Fcgr2b^tm1Ttk	J:120905
Icam1^tm1Bay/Icam1^tm1Bay		B6.129S7-Icam1^tm1Bay/J	J:193592
Models with phenotypic similarity to human disease where etiologies are distinct.²
Ank1^MRI23420/Ank1^MRI23420		SJL/J-Ank1^MRI23420	J:187820
Ank1^nb/Ank1^nb		involves: C57BL/6J * WB/Re	J:111131
Hmox1^tm1Mlee/Hmox1^tm1Mlee		involves: 129S2/SvPas * BALB/c	J:153083
Ifng^tm1Ts/Ifng^tm1Ts		involves: 129S7/SvEvBrd * C57BL/6	J:189794
Pklr^char4/Pklr^char4		involves: A/J * C57BL/6	J:86735, J:141722

¹Human genes are associated with this disease. Mouse model genotypes include mutations in the orthologs of these human genes.
²Human genes are associated with this disease. Mouse model genotypes do not include mutations in the orthologs of these human genes.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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