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| Nomenclature |
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Symbol:
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Waptm2(rtTA)Kuw
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Name:
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whey acidic protein;
targeted mutation 2, Kay Uwe Wagner
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MGI ID: |
MGI:3799057 |
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Gene:
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Wap
Location:
Chr11:6635482-6638637 bp, - strand
Genetic Position: Chr11,
4.61 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:148684
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The coding sequence for rtTA was inserted into the 5'-UTR along with a floxed neomycin selection cassette. The neo selection cassette was eliminated in founder line 7A3 by crossing properly targeted mice to Tg(MMTV-cre)1Mam transgenic animals. When mice were given doxycycline, transgene expression was restricted to mammary epithelial cells as determined by crosses with two different rtTA reporter strains. (J:148684)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:148684
Creamer BA et al.,
"Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging."
Genesis 2009 Apr;47(4):234-45
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All: |
2 reference(s)
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Analysis Tools
