Lep<ob> Spontaneous Allele Detail MGI Mouse (MGI:1856424)

Lep^ob
Spontaneous Allele Detail

Nomenclature

Symbol:	Lep^ob
Name:	leptin; obese
MGI ID:	MGI:1856424
Synonyms:	ob
Gene:	Lep Location: Chr6:29010221-29023876 bp, + strand Genetic Position: Chr6, 10.5 cM

Lep^ob/Lep^ob

Show the 2 image(s) involving this allele.

Mutation
origin

Strain of Origin:

STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s

Mutation
description

Allele Type:	Spontaneous
Mutation:	Single point mutation
	Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). (J:20512, J:29081, J:45748)
Inheritance:	Recessive

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 5 strains available Cell Lines: 0 lines available
Carrying any Lep Mutation:	5 strains or lines available

Expression

In Mice Carrying this Mutation:

Phenotype
summary

Phenotype Summary by Mammalian Phenotype terms

(show or hide all annotated terms)

Genotypes are listed in the next section.

Key:

hm	homozygous	ht	heterozygous
cn	conditional genotype	cx	complex: > 1 genome feature
tg	involves transgenes	ot	other: hemizygous, indeterminate,...
N	normal phenotype		expected model not found