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| Nomenclature |
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Symbol:
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Relnrl
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Name:
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reelin;
reeler
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MGI ID: |
MGI:1856398 |
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Synonyms: |
rl, rl-, rlJ |
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Gene:
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Reln
Location:
Chr5:21390272-21850520 bp, - strand
Genetic Position: Chr5,
8.0 cM, cytoband A3-B1
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The Relnrl/Relnrl mouse
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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"snowy-bellied" stock and unspecified inbred strain
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Deletion |
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This allele comprises, minimally, a 150 kb deletion between D5Mit61 and D5Mit72. (J:24458) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| Expression |
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
Relnrl, reeler, recessive. The reeler mutation was identified by Falconer (J:13038) as a spontaneous mutation in a mildly inbred stock. Reeler homozygotes are unable to keep their hindquarters upright and frequently fall over on their sides when walking or running. Viability and fertility are much reduced, particularly when the gene is on an inbred genetic background, but viability is greatly improved on a hybrid background, and an occasional female or rarely a male may breed (J:5312). Healthy reeler mice have fairly normal behavior except for difficulties in locomotion (J:5359). The neuropathology of Relnrl/Relnrl mice has been studied very extensively. These studies were summarized and critically reviewed by Goffinet (J:12281). Briefly, the cerebellum is greatly reduced in size, and the typical organization and lamination of the cerebellar cortex, the cerebral cortex, and the hippocampus are altered. Abnormal arrangement of neurons is also seen in other brain structures. Autoradiographic studies of development of the cerebral cortex in reelers have shown that the different classes of neurons take their origin from the ependymal layer at the normal time but migrate abnormally and come to rest in abnormal relations to each other (J:12728). The earliest cortical neurons may be overly adhesive and may block migration of later neurons (J:26896). The abnormal arrangement of neurons in other parts of the brain is the result of a similar abnormal pattern of migration. In spite of abnormal location of the neurons and also their greatly reduced number in the cerebellum, relatively normal cell connections are established. Chimeras produced by fusion between Relnrl/Relnrl and +/+ embryos indicated that factors extrinsic to the abnormally positioned Purkinje cells were defective in reeler (J:15345).
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| References |
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Original: |
J:13038
Falconer DS,
"Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse."
J Genet 1951;50():192-201
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All: |
168 reference(s)
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