Gabrptm1Dgen
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Gabrptm1Dgen
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Name:
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gamma-aminobutyric acid (GABA) A receptor, pi;
targeted mutation 1, Deltagen
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MGI ID: |
MGI:3604585 |
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Gene:
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Gabrp
Location:
Chr11:33550781-33578959 bp, - strand
Genetic Position: Chr11,
19.21 cM
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Mutation
origin |
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Mutant Cell Line:
| 6646 (Deltagen) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101679
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the gallbladder, moderate levels in lung, skin, seminal vesicle, prostate gland, ovary and uterus and low levels in subcortical region, olfactory bulb, eye, Harderian glands, liver, pancreas, kidney, thymus, urinary bladder, pituitary gland, salivary gland, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, coagulating gland and white fat. Beta-galactosidase expression from this allele is detectable in brain, spinal cord, thymus, lung, liver, pancreas, kidney, trachea, skeletal muscle, skin, testis, uterus and cervix. Most striking expression was detected in bronchial and tracheal epithelium. Staining was observed in different tissue and cell types, including epithelium and neurons.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Deltagen, Inc.
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| References |
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Original: |
J:101679
Deltagen Inc,
"NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
MGI Direct Data Submission 2005;():
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All: |
1 reference(s)
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Analysis Tools
