Efemp2tm1Dgen
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Efemp2tm1Dgen
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Name:
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epidermal growth factor-containing fibulin-like extracellular matrix protein 2;
targeted mutation 1, Deltagen
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MGI ID: |
MGI:3604551 |
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Synonyms: |
Fbln4-, fibulin-4- |
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Gene:
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Efemp2
Location:
Chr19:5473973-5481853 bp, + strand
Genetic Position: Chr19,
4.33 cM, cytoband A
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Efemp2tm1Dgen/Efemp2+ mice exhibit abnormal aorta morphology
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Mutant Cell Line:
| 2561 (Deltagen) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101679
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues tested, strong beta-galactosidase expression from this allele is detectable in brain, spinal cord, eyes, Harderian glands, thymus, spleen, lymph nodes, aorta, heart, lung, liver, gallbladder, pancreas, kidney, urinary bladder, trachea, larynx, esophagus, thyroid gland, pituitary gland, adrenal glands, salivary glands, tongue, skeletal muscle, skin, male and female reproductive systems. In many tissues lacZ is expressed in smooth muscle cells.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Deltagen, Inc.
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| References |
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Original: |
J:101679
Deltagen Inc,
"NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
MGI Direct Data Submission 2005;():
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All: |
5 reference(s)
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Analysis Tools
