Ccktm1Dgen
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Ccktm1Dgen
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Name:
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cholecystokinin;
targeted mutation 1, Deltagen
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MGI ID: |
MGI:3604503 |
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Gene:
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Cck
Location:
Chr9:121489825-121495689 bp, - strand
Genetic Position: Chr9,
72.43 cM, cytoband F4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101679
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the brain cortex, moderate levels in whole brain, subcortical region, cerebellum and olfactory bulb, and low levels in brainstem, spinal cord, eye, Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, cecum, colon, testis, epididymis, seminal vesicle, coagulating gland, prostate gland, ovary, uterus and white fat. However, beta-galactosidase expression from this allele is detectable in only in brain, kidney and testis, with moderate lacZ expression detected in some regions of the whole mount brain including areas of the cortex and hippocampus. On coronal sections of brain, very weak staining was observed in a few cells of the pyramidal cell layer in hippocampus. Strong, scattered expression was observed in renal medulla and papilla. Strong staining was also observed in a few spermatogenic cells in the testis.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Deltagen, Inc.
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| References |
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Original: |
J:101679
Deltagen Inc,
"NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
MGI Direct Data Submission 2005;():
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All: |
1 reference(s)
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Analysis Tools
