Adamts5tm1Dgen
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Adamts5tm1Dgen
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Name:
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a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2);
targeted mutation 1, Deltagen
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MGI ID: |
MGI:3604488 |
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Gene:
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Adamts5
Location:
Chr16:85858170-85901125 bp, - strand
Genetic Position: Chr16,
48.34 cM
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Mutation
origin |
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Mutant Cell Line:
| 8491 (Deltagen) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:101679
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An IRES-lacZ gene was inserted into and replaced 134 nucleotides of exon 2. The deleted region includes that encoding the catalytic active site as well as most of the putative muscle regulatory factor-binding enhancer. The highest levels of RNA transcripts are detectable in pancreas, adrenal gland and white fat. Moderate levels of RNA transcripts are detectable in: olfactory bulb, heart, lung, thymus, skin, gallbladder, testis, epididymis and coagulating gland. Lower levels of RNA transcripts are also detectable in: whole brain, cortex, subcortical region, cerebellum, brainstem, spinal cord, eye, Harderian glands, liver, kidney, spleen, lymph nodes, bone marrow, urinary bladder, pituitary gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, seminal vesicle, prostate gland and uterus. LacZ expression was detected in all organs examined. (J:148803)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Deltagen, Inc.
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| References |
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Original: |
J:101679
Deltagen Inc,
"NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
MGI Direct Data Submission 2005;():
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All: |
7 reference(s)
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Analysis Tools
