Htr5atm1Dgen
Targeted Allele Detail
|
|
| Nomenclature |
|
Symbol:
|
Htr5atm1Dgen
|
|
Name:
|
5-hydroxytryptamine (serotonin) receptor 5A;
targeted mutation 1, Deltagen
|
|
MGI ID: |
MGI:3604475 |
|
Gene:
|
Htr5a
Location:
Chr5:27841947-27855086 bp, + strand
Genetic Position: Chr5,
13.24 cM, cytoband A3-B
|
|
Mutation
origin |
|
Mutant Cell Line:
| 893 (Deltagen) |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:101679
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutation: | |
Disruption caused by insertion of vector |
| |
|
Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. Low levels of RNA transcripts are detectable in brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, eye, skin, pituitary gland, adrenal gland, ovary, and white fat but not in Harderian glands, heart, lung, liver, pancreas, kidney, spleen, thymus, lymph nodes, bone marrow, gallbladder, urinary bladder, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, seminal vesicle, coagulating gland, prostate gland and uterus. LacZ (beta-galactosidase) expression is detectable in brain and esophagus. In brain, staining is restricted to the cerebellum with Purkinje cells and nuclei in the granular layer displaying expression.
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
See also,
data
as provided by Deltagen, Inc.
|
| References |
|
Original: |
J:101679
Deltagen Inc,
"NIH initiative supporting placement of Deltagen, Inc. mice into public repositories"
MGI Direct Data Submission 2005;():
|
|
All: |
1 reference(s)
|
|
|
Analysis Tools
