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| Nomenclature |
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Symbol:
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Waptm1Kuw
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Name:
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whey acidic protein;
targeted mutation 1, Kay-Uwe Wagner
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MGI ID: |
MGI:3584430 |
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Gene:
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Wap
Location:
Chr11:6635482-6638637 bp, - strand
Genetic Position: Chr11,
4.61 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:100003
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The first exon and the splicing signal at the first exon-intron junction have been replaced by a loxP-flanked Pgk-neo cassette. No whey acidic protein mRNA or protein is detectable by northern or western blot analysis, respectively, in the mammary glands or milk on day 1 of lactation of dams homozygous for the targeted allele, nor is the protein detected in their secretory alveoli by immunohistochemical analysis. Expression in heterozygous dams does not differ significantly from that in wild-type mothers.(J:100003)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:100003
Triplett AA et al.,
"Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells."
Genesis 2005 Aug 16;43(1):1-11
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All: |
1 reference(s)
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Analysis Tools
