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| Nomenclature |
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Symbol:
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Adcy10tm1Lex
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Name:
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adenylate cyclase 10;
targeted mutation 1, Lexicon Genetics
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MGI ID: |
MGI:3529121 |
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Synonyms: |
Lex/Sacytm1 KO, sAC-, Sacy-, Sacytm1Jgo, SacytmLex |
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Gene:
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Adcy10
Location:
Chr1:165485183-165576774 bp, + strand
Genetic Position: Chr1,
72.83 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88649
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An IRES-lacZ gene replaced exons 2, 3, and 4. In situ analysis confirmed the absence of endogenous protein in the testis. RT-PCR showed a very low level of transcript expression in the testis that is likely due to read through of the IRES-lacZ cassette. This mutant transcript cannot produce functional protein due to frameshift mutations. (J:88649)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Lexicon Genetics, Inc.
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| References |
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Original: |
J:88649
Esposito G et al.,
"Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect."
Proc Natl Acad Sci U S A 2004 Mar 2;101(9):2993-8
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All: |
10 reference(s)
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Analysis Tools
