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| Nomenclature |
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Symbol:
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Igf2bp1Gt(OST33739)Lex
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Name:
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insulin-like growth factor 2 mRNA binding protein 1;
gene trap OST33739, Lexicon Genetics
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MGI ID: |
MGI:3043746 |
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Synonyms: |
Igf2bp1Gt(Betageo)1Fcn, Imp1-, Zbp1- |
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Gene:
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Igf2bp1
Location:
Chr11:95957163-96005940 bp, - strand
Genetic Position: Chr11,
59.08 cM
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Mutation
origin |
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Mutant Cell Line:
| OST33739 (Lexicon Genetics) |
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Germline Transmission:
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Earliest citation of germline transmission:
J:89882
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Parent Cell Line:
| Lex-1 (ES Cell) |
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Strain of Origin:
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129S5/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Gene trapped |
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Mutation: | |
Insertion of gene trap vector |
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Mutation details: A retroviral gene trap vector, containing a 5' LTR followed by a splice acceptor, beta-geo, PGK-puro, stop codons, a splice donor, and a 3' LTR, was inserted into intron 2. Insertion of the gene trap vector led to deletion of the second RNA recognition motif and the four K-homology modules, known to be essential for RNA binding, cytoplasmic granule formation, and subcytoplasmic localization. Normal transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:89882)
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Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID | GenBank ID | Method |
Tag Location (trapped strand)* | Select |
* GRCm38
(strand of gene trap mutagenesis) |
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Genome Context: |
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Genome Browser view of this mutation
Blue line marks
approximate position of gene trap insertion
156 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
See also,
data
as provided by Lexicon Genetics, Inc.
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| References |
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Original: |
J:89882
Hansen TV et al.,
"Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice."
Mol Cell Biol 2004 May;24(10):4448-64
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All: |
5 reference(s)
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Analysis Tools
