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| Nomenclature |
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Symbol:
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Oca2p-J
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Name:
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oculocutaneous albinism II;
pink-eyed dilution Jackson
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MGI ID: |
MGI:1856127 |
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Synonyms: |
pJ |
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Gene:
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Oca2
Location:
Chr7:63495130-63791887 bp, + strand
Genetic Position: Chr7,
28.0 cM
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Diluted coat color and pink eyes of Oca2p-J/Oca2p-J mice (lower) compared to the Oca2p-J/+ mouse (upper)
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3H/HeJ
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Deletion |
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Southern blot analysis of Sst1-digested genomic DNA from this allele, probed with a 1.0-kb Dra III fragment derived from clone MC2701 cDNA revealed a deletion of two exon-bearing fragments (6.9 and 10.0 kb) found in wild-type DNA from the pink-eyed dilution locus. This allele was shown to be allelic to Oca2p by a complementation test. (J:2206) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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| References |
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Original: |
J:2108
Lyon MF et al.,
"Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse."
Proc Natl Acad Sci U S A 1992 Aug 1;89(15):6968-72
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All: |
5 reference(s)
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