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| Nomenclature |
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Symbol:
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Myo15sh2
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Name:
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myosin XV;
shaker 2
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MGI ID: |
MGI:1857036 |
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Synonyms: |
sh2 |
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Gene:
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Myo15
Location:
Chr11:60282841-60341871 bp, + strand
Genetic Position: Chr11,
33.9 cM
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Mutation
origin |
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Strain of Origin:
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Mixed stock
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Mutation
description |
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Allele
Type: |
Radiation induced |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| Expression |
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Notes |
The Myo15sh2 mutation was discovered by Dobrovolskaia-Zavadskaia (J:15021) in descendants of an irradiated male. Viability and fertility are nearly normal. This mutant is very similar in behavior and pathology to Myo7ash1, with the exception that the abnormalities are observed a little earlier in Myo15sh2. Homozygotes appear to be deaf from the beginning, and the saccular macula is abnormal at birth (J:13046). The stria vascularis appears normal by light microscopy at 2 weeks of age, but begins to show degenerative changes shortly thereafter. Many of the cells contain electron-dense inclusions filled with a fine granular material (J:6781). At 2.5 months old, the type I hair cells of the cristae ampullares and maculae utriculi contain rod-shaped inclusion bodies composed of actin filaments (J:6873).
Myo15sh2 was shown by complementation tests to be at a different locus from Myo7ash1 (J:28674), and linkage with Egfr on Chr 11 was established (J:303). Detailed linkage and physical maps of the Myo15sh2 region of Chr 11 have been constructed (J:40351).
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| References |
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Original: |
J:15021
Dobrovolskaia-Zavasdkaia N,
"L'irradiation des testicules et l'heredite chez la souris"
Arch Biol (Liege) 1928;38():457-501
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All: |
27 reference(s)
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