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| Nomenclature |
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Symbol:
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Lama2dy-2J
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Name:
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laminin, alpha 2;
dystrophia muscularis 2 Jackson
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MGI ID: |
MGI:1856027 |
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Synonyms: |
2J, dy2J |
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Gene:
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Lama2
Location:
Chr10:26701094-27336748 bp, - strand
Genetic Position: Chr10,
20.0 cM, cytoband A4-B1
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Lama2dy-2J/Lama2dy-2J mouse
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Mutation
description |
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Allele
Type: |
Spontaneous |
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Mutation: |
Single point mutation |
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The G to A mutation in a splice site consensus sequence causes abnormal splicing and expression of multiple mRNAs. One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. (J:21367, J:25954) |
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Inheritance: |
Recessive |
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Phenotype
summary
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Phenotype Summary by Mammalian Phenotype terms
(show or
hide all annotated terms)
Genotypes are listed in the next section.
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Key:
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| hm |
homozygous |
ht |
heterozygous |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
| tg |
involves transgenes |
ot |
other: hemizygous, indeterminate,... |
| N |
normal phenotype |
 |
expected model not found |
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Phenotypic
data by
genotype
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Phenotypic Data by Genotype
(show or
hide all phenotypic details)
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Disease
models
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| References |
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Original: |
J:5151
Meier H et al.,
"Muscular dystrophy in the mouse caused by an allele at the dy-locus."
Life Sci 1970 Feb 8;9(3):137-44
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All: |
22 reference(s)
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