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| Nomenclature |
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Symbol:
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Tg(APOE-FGF23*R176Q)#Ack
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Name:
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transgene insertion, Andrew C Karaplis
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MGI ID: |
MGI:5465569 |
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Synonyms: |
FGF23-TG |
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Transgene:
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Tg(APOE-FGF23*R176Q)#Ack
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the human APOE promoter with exon 1 and part of exon 2 and the human FGF23 cDNA with the R176Q mutation tagged with a myc epitope followed by the APOE poly(A) and hepatic control region. The APOE promoter drives expression of FGF23 in the liver. Two lines were established however, the pound symbol (#) is used because the line is not specified and lines are pooled. (J:93981)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:93981
Bai X et al.,
"Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders."
Endocrinology 2004 Nov;145(11):5269-79
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All: |
2 reference(s)
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Analysis Tools
