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| Nomenclature |
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Symbol:
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Srgap3tm1.1Zi
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Name:
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SLIT-ROBO Rho GTPase activating protein 3;
targeted mutation 1.1, Dusan Bartsch
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MGI ID: |
MGI:5465281 |
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Gene:
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Srgap3
Location:
Chr6:112717971-112947266 bp, - strand
Genetic Position: Chr6,
52.54 cM, cytoband E3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:192388
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 3 was replaced with a modified one with a premature stop codon. This mutation resembled the breakpoint of the t(3; X)(p25;p11) translocation. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of the modified exon 3. Western blot anlaysis confirmed the absence of protein expression in the adult cortex. (J:192388)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Srgap3 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:192388
Waltereit R et al.,
"Srgap3(-)/(-) mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes."
FASEB J 2012 Nov;26(11):4418-28
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All: |
1 reference(s)
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Analysis Tools
