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| Nomenclature |
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Symbol:
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Tg(Thy1-APPArc)M8Cagr
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Name:
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transgene insertion M8, Caroline Graff
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MGI ID: |
MGI:5463435 |
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Synonyms: |
TgAPParc, Thy1.2-hAPParc |
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Transgene:
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Tg(Thy1-APPArc)M8Cagr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The Arctic mutation, an A>G nucleotide substitution resulting in a glutamic acid to glycine amino acid substitution at codon 693 (E693G), was introduced into a human cDNA of APP (695 isoform) by site-directed mutagenesis and a Kozak sequence was introduced upstream of ATG to enhance translation. This construct was placed under the control of the mouse Thy1.2 expression cassette that drives expression of the transgene specifically in neurons. Two lines were made, M7 and M8. M8 is the high expressor line and hemizygous mice have an approximately 3-fold higher expression of human APP compared to endogenous App. (J:168288)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:168288
Ronnback A et al.,
"Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model."
Neurobiol Aging 2011 Feb;32(2):280-92
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All: |
2 reference(s)
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Analysis Tools
