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| Nomenclature |
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Symbol:
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Notch3tm1.1Dwr
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Name:
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notch 3;
targeted mutation 1.1, Mieke Dewerchin
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MGI ID: |
MGI:5462093 |
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Synonyms: |
Notch3Arg170Cys, Notch3m |
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Gene:
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Notch3
Location:
Chr17:32120820-32166880 bp, - strand
Genetic Position: Chr17,
17.37 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:191454
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 4 was replaced with one in which a C to T transition resulted in the amino acid substitution of cysteine for arginine at position 170 (R170C). A silent mutation creating a HincII site was introduced in exon 4 for genotyping purposes. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 5 (J:191454)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Notch3 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:191454
Wallays G et al.,
"Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy."
Arterioscler Thromb Vasc Biol 2011 Dec;31(12):2881-8
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All: |
1 reference(s)
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Analysis Tools
