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| Nomenclature |
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Symbol:
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Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
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Name:
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transgene insertion, Timothy J Sargeant
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MGI ID: |
MGI:5451190 |
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Synonyms: |
HexTg, P8Hex (+) |
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Transgene:
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Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The proximal murine Hexb promoter (330 bp) drives expression of the tet-transactivator from the pTet-off advanced plasmid and tet responsive element (TRE-tight) drives expression of a full lenght mouse Hexb cDNA. Expression is seen only in the nervous tissue, skin and skeletal muscle. In the cerebral cortex expression of the tet-transactivator transcript is evenly distributed through the cortex. (J:190450)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:190450
Sargeant TJ et al.,
"Characterization of inducible models of Tay-Sachs and related disease."
PLoS Genet 2012 Sep;8(9):e1002943
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All: |
1 reference(s)
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Analysis Tools
