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| Nomenclature |
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Symbol:
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Tg(SOD1*)DF7Yaw
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Name:
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transgene insertion DF7, Yasuhiro Watanabe
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MGI ID: |
MGI:5449420 |
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Synonyms: |
DF |
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Transgene:
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Tg(SOD1*)DF7Yaw
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the entire genomic sequence of human SOD1 with a 2-bp deletion at codon 126 and a FLAG sequence at the C-terminal. The mutation causes a frame shift and results in premature stop sequence at codon 131, resulting in a mutant protein of 130 amino acids. No SOD1 activity could be detected, however, Western and Northern analysis indicated protein expression and presence of RNA, respectively. Two lines were established, DF2 and DF7. (J:97932)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:97932
Watanabe Y et al.,
"Mouse motor neuron disease caused by truncated SOD1 with or without C-terminal modification."
Brain Res Mol Brain Res 2005 Apr 27;135(1-2):12-20
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All: |
1 reference(s)
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Analysis Tools
