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| Nomenclature |
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Symbol:
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Tg(SOD1*G85R)#Roos
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Name:
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transgene insertion, Raymond Roos
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MGI ID: |
MGI:5448547 |
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Synonyms: |
G85R |
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Transgene:
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Tg(SOD1*G85R)#Roos
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of the human SOD1 carrying a glycine to arginine substitution at amino acid 85 (G86R), a mutation associated with familial amyotrophic lateral sclerosis. In addition, loxP sites were engineered to flank the G86R sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:147156)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:147156
Wang L et al.,
"Wild type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse."
Hum Mol Genet 2009 Feb 19;18(9):1642-51
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All: |
2 reference(s)
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Analysis Tools
