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| Nomenclature |
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Symbol:
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Scn1atm2.1Wac
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Name:
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sodium channel, voltage-gated, type I, alpha;
targeted mutation 2.1, William A Catterall
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MGI ID: |
MGI:5447489 |
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Gene:
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Scn1a
Location:
Chr2:66270781-66440840 bp, - strand
Genetic Position: Chr2,
39.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:189897
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 25 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 25 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:189897)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Scn1a Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:189897
Cheah CS et al.,
"Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome."
Proc Natl Acad Sci U S A 2012 Sep 4;109(36):14646-51
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All: |
2 reference(s)
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Analysis Tools
